Phexx has an MOA specifically designed to prevent pregnancy

Phexx is a non-hormonal birth control containing active ingredients lactic acid, citric acid, and potassium bitartrate.2 Phexx is a first-in-class vaginal pH modulator (VPM)1; it is not a spermicide.

The introduction of seminal fluid changes vaginal pH. The active ingredients in Phexx prevent pregnancy by maintaining an acidic vaginal pH, which creates an inhospitable environment for sperm.2-5

In vitro studies with Phexx show immediate sperm motility reduction through the maintenance of an acidic vaginal pH and the creation of a viscous gel barrier.2-5

How Phexx works

Vaginal pH modulation

Phexx maintains an acidic vaginal pH, even in the presence of semen, which creates an inhospitable environment for sperm.2-5

The buffering capacity of Phexx reduces the availability of calcium ions, which are needed to drive sperm tail movement.6

Vaginal pH with Phexxa
3.5 - 4.5
Vaginal pH without Phexxa
6.5 - 7.2
Graph showing range of vaginal pH with and without Phexx
aIn the presence of semen.
Diagram of seminal fluid and Phexxi gel inside the vagina  copy

Unique gel formulation

The bioadhesive properties of Phexx keep the gel in place to maintain an acidic vaginal pH. The viscous properties of Phexx make it difficult for sperm to travel toward the cervix.2-5

Diagram showing Phexx gel adhering to vaginal tissue

Images are for illustrative purposes only.

Using Phexx is easy7: 1 Dose/1 Act.
See how to properly administer Phexx for best results.

Proven contraceptive protection.

Proven contraceptive protection.

 

Results from the clinical trial show Phexx is effective and safe.

Dosing and prescribing Phexx.

Dosing and prescribing Phexx.

 

What does 1 dose/1 act mean?

It’s time to get personal.

It’s time to get personal.

 

Who is right for Phexx?
Women who are simply seeking pregnancy prevention.

INDICATION

Phexx is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.

LIMITATIONS OF USE

Phexx is not effective for the prevention of pregnancy when administered after intercourse.

IMPORTANT SAFETY INFORMATION

WARNINGS AND PRECAUTIONS

Few cases (0.36%) of adverse reactions of cystitis, pyelonephritis and other upper urinary tract infection (UTI) have been reported in Phexxi clinical studies. Of these, one case of pyelonephritis was considered serious and required hospitalization. Avoid use of Phexx in females with history of recurrent urinary tract infection or urinary tract abnormalities.

ADVERSE REACTIONS

Most common adverse reactions were vulvovaginal burning sensation, pruritus, mycotic infection, genital discomfort (including male partners); urinary tract infection, bacterial vaginosis, vaginal discharge, and dysuria. Patients should consult their healthcare provider for severe or prolonged genital irritation or urinary tract symptoms.

Advise the patient:

  • To discontinue Phexx if they develop a local hypersensitivity reaction.
  • That Phexx does not protect against HIV infection or other sexually transmitted infections.
  • Avoid Phexx use with vaginal rings.

To report SUSPECTED ADVERSE REACTIONS, contact Evofem at toll-free phone 1-833-EVFMBIO or you may contact FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information for Phexx.

References:

  1. Phexxi® Vaginal Gel. Medi-Span®; June 8, 2020.
  2. Phexx® [Prescribing Information]. Evofem Biosciences, Inc.: San Diego, CA; April 2025.
  3. Bayer LL, Jensen JT. ACIDFORM: a review of evidence. Contraception. 2014;90(1):11-18.
  4. Garg S, Anderson RA, Chany CJ, et al. Properties of a new acid-buffering bioadhesive vaginal formuation (ACIDFORM). Contraception. 2001;64(1):67-75.
  5. Amaral E, Perdigão A, Souza MH, et al. Postcoital testing after the use of bio-adhesive acid buffering gel (ACIDFORM) and a 2% nonoxynol-9 product. Contraception. 2004;70(6):492-497.
  6. Zhou J, Chen L, Li J, et al. The semen pH affects sperm motility and capacitation. PLoS One. 2015;10(7):1-15.
  7. Data on file. Evofem Biosciences, Inc.

IMPORTANT SAFETY INFORMATION

WARNINGS AND PRECAUTIONS

Few cases (0.36%) of adverse reactions of cystitis, pyelonephritis and other upper urinary tract infection (UTI) have been reported in Phexx clinical studies. Of these, one case of pyelonephritis was considered serious and required hospitalization. Avoid use of Phexx in females with history of recurrent urinary tract infection or urinary tract abnormalities.

ADVERSE REACTIONS

Most common adverse reactions were vulvovaginal burning sensation, pruritus, mycotic infection, genital discomfort (including male partners); urinary tract infection, bacterial vaginosis, vaginal discharge, and dysuria. Patients should consult their healthcare provider for severe or prolonged genital irritation or urinary tract symptoms.

Advise the patient:

  • To discontinue Phexx if they develop a local hypersensitivity reaction.
  • That Phexx does not protect against HIV infection or other sexually transmitted infections.
  • Avoid Phexx use with vaginal rings.

To report SUSPECTED ADVERSE REACTIONS, contact Evofem at toll-free phone 1-833-EVFMBIO or you may contact FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information for Phexx.

INDICATION

Phexx is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.

LIMITATIONS OF USE

Phexx is not effective for the prevention of pregnancy when administered after intercourse.